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Gain-of-Function Mutations: An Emerging Advantage for Cancer Biology
Advances in next-generation sequencing have identified thousands of genomic variants that perturb the normal functions of proteins, further contributing to diverse phenotypic consequences in cancer. Elucidating the functional pathways altered by loss-of-function (LOF) or gain-of-function (GOF) mutat...
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| Publicado en: | Trends Biochem Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6944532/ https://ncbi.nlm.nih.gov/pubmed/31047772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2019.03.009 |
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