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Gain and loss of function mutations in biological chemical reaction networks: a mathematical model with application to colorectal cancer cells

This paper studies a system of Ordinary Differential Equations modeling a chemical reaction network and derives from it a simulation tool mimicking Loss of Function and Gain of Function mutations found in cancer cells. More specifically, from a theoretical perspective, our approach focuses on the de...

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Библиографические подробности
Опубликовано в: :J Math Biol
Главные авторы: Sommariva, Sara, Caviglia, Giacomo, Piana, Michele
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2021
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096774/
https://ncbi.nlm.nih.gov/pubmed/33945019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00285-021-01607-0
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