A gain of function mutation in DHT synthesis in castration-resistant prostate cancer

Growth of prostate cancer cells is dependent upon androgen stimulation of the androgen receptor (AR). Dihydrotestosterone (DHT), the most potent androgen, is usually synthesized in the prostate from testosterone secreted by the testis. Following chemical or surgical castration, prostate cancers usua...

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Main Authors: Chang, Kai-Hsiung, Li, Rui, Kuri, Barbara, Lotan, Yair, Roehrborn, Claus G., Liu, Jiayan, Vessella, Robert, Nelson, Peter, Kapur, Payal, Guo, Xiaofeng, Mirzaei, Hamid, Auchus, Richard J., Sharifi, Nima
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931012/
https://ncbi.nlm.nih.gov/pubmed/23993097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.07.029
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