A gain of function mutation in DHT synthesis in castration-resistant prostate cancer

Growth of prostate cancer cells is dependent upon androgen stimulation of the androgen receptor (AR). Dihydrotestosterone (DHT), the most potent androgen, is usually synthesized in the prostate from testosterone secreted by the testis. Following chemical or surgical castration, prostate cancers usua...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chang, Kai-Hsiung, Li, Rui, Kuri, Barbara, Lotan, Yair, Roehrborn, Claus G., Liu, Jiayan, Vessella, Robert, Nelson, Peter, Kapur, Payal, Guo, Xiaofeng, Mirzaei, Hamid, Auchus, Richard J., Sharifi, Nima
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931012/
https://ncbi.nlm.nih.gov/pubmed/23993097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.07.029
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