A gain of function mutation in DHT synthesis in castration-resistant prostate cancer

Growth of prostate cancer cells is dependent upon androgen stimulation of the androgen receptor (AR). Dihydrotestosterone (DHT), the most potent androgen, is usually synthesized in the prostate from testosterone secreted by the testis. Following chemical or surgical castration, prostate cancers usua...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chang, Kai-Hsiung, Li, Rui, Kuri, Barbara, Lotan, Yair, Roehrborn, Claus G., Liu, Jiayan, Vessella, Robert, Nelson, Peter, Kapur, Payal, Guo, Xiaofeng, Mirzaei, Hamid, Auchus, Richard J., Sharifi, Nima
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931012/
https://ncbi.nlm.nih.gov/pubmed/23993097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.07.029
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires