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Emissive Synthetic Cofactors: A Highly Responsive NAD(+) Analogue Reveals Biomolecular Recognition Features

Apart from its vital function as a redox cofactor, nicotinamide adenine dinucleotide (NAD(+)) has emerged as a crucial substrate for NAD(+)-consuming enzymes, including poly(ADP-ribosyl)transferase 1 (PARP1) and CD38/CD157. Their association with severe diseases, such as cancer, Alzheimer’s disease,...

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Bibliographic Details
Published in:Chemistry
Main Authors: Feldmann, Jonas, Li, Yao, Tor, Yitzhak
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944523/
https://ncbi.nlm.nih.gov/pubmed/30648291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201805520
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