Emissive Synthetic Cofactors: Enzymatic Interconversions of (tz)A Analogues of ATP, NAD(+), NADH, NADP(+), and NADPH

A series of enzymatic transformations, which generate visibly emissive isofunctional cofactors based on an isothiazolo[4,3-d]pyrimidine analogue of adenosine ((tz)A), was developed. Nicotinamide adenylyl transferase condenses nicotinamide mononucleotide and (tz)ATP to yield N(tz)AD(+), which can be...

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Bibliographic Details
Published in:	Angew Chem Int Ed Engl
Main Authors:	Hallé, François, Fin, Andrea, Rovira, Alexander R., Tor, Yitzhak
Format:	Artigo
Language:	Inglês
Published:	2017
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5771816/ https://ncbi.nlm.nih.gov/pubmed/29228460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201711935
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Emissive Synthetic Cofactors: Enzymatic Interconversions of (tz)A Analogues of ATP, NAD(+), NADH, NADP(+), and NADPH

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