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Emissive Synthetic Cofactors: Enzymatic Interconversions of (tz)A Analogues of ATP, NAD(+), NADH, NADP(+), and NADPH
A series of enzymatic transformations, which generate visibly emissive isofunctional cofactors based on an isothiazolo[4,3-d]pyrimidine analogue of adenosine ((tz)A), was developed. Nicotinamide adenylyl transferase condenses nicotinamide mononucleotide and (tz)ATP to yield N(tz)AD(+), which can be...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5771816/ https://ncbi.nlm.nih.gov/pubmed/29228460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201711935 |
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