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Emissive Synthetic Cofactors: An Isomorphic, Isofunctional, and Responsive NAD(+) Analogue
The synthesis, photophysics, and biochemical utility of a fluorescent NAD(+) analogue based on an isothiazolo[4,3-d]pyrimidine core (N(tz)AD(+)) are described. Enzymatic reactions, photophysically monitored in real time, show N(tz)AD(+) and N(tz)ADH to be substrates for yeast alcohol dehydrogenase a...
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| Udgivet i: | J Am Chem Soc |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5766281/ https://ncbi.nlm.nih.gov/pubmed/29043790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05852 |
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