Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds

The imidazo[2,1-b]thiazole-5-carboxamides (ITAs) are a promising class of anti-tuberculosis agents shown to have potent activity in vitro and to target QcrB, a key component of the mycobacterial cytochrome bcc-aa3 super complex critical for the electron transport chain. Herein we report the intracel...

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Udgivet i:PLoS One
Main Authors: Moraski, Garrett C., Deboosère, Nathalie, Marshall, Kate L., Weaver, Heath A., Vandeputte, Alexandre, Hastings, Courtney, Woolhiser, Lisa, Lenaerts, Anne J., Brodin, Priscille, Miller, Marvin J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944458/
https://ncbi.nlm.nih.gov/pubmed/31905374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227224
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