Imidazo[1,2-a]Pyridine-3-Carboxamides Are Active Antimicrobial Agents against Mycobacterium avium Infection In Vivo

A panel of six imidazo[1,2-a]pyridine-3-carboxamides (IAPs) were shown to have low-micromolar activity against Mycobacterium avium strains. Compound ND-10885 (compound 2) showed significant activity in the lung, spleen, and liver in a mouse M. avium infection model. A combined regimen consisting of...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Moraski, Garrett C., Cheng, Yong, Cho, Sanghyun, Cramer, Jeffrey W., Godfrey, Alexander, Masquelin, Thierry, Franzblau, Scott G., Miller, Marvin J., Schorey, Jeffery
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958206/
https://ncbi.nlm.nih.gov/pubmed/27216051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00618-16
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