Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives

Simulations of close relatives and identical by descent (IBD) segments are common in genetic studies, yet most past efforts have utilized sex averaged genetic maps and ignored crossover interference, thus omitting features known to affect the breakpoints of IBD segments. We developed Ped-sim, a meth...

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Pubblicato in:PLoS Genet
Autori principali: Caballero, Madison, Seidman, Daniel N., Qiao, Ying, Sannerud, Jens, Dyer, Thomas D., Lehman, Donna M., Curran, Joanne E., Duggirala, Ravindranath, Blangero, John, Carmi, Shai, Williams, Amy L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944377/
https://ncbi.nlm.nih.gov/pubmed/31860654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007979
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