Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives

Simulations of close relatives and identical by descent (IBD) segments are common in genetic studies, yet most past efforts have utilized sex averaged genetic maps and ignored crossover interference, thus omitting features known to affect the breakpoints of IBD segments. We developed Ped-sim, a meth...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:PLoS Genet
Κύριοι συγγραφείς: Caballero, Madison, Seidman, Daniel N., Qiao, Ying, Sannerud, Jens, Dyer, Thomas D., Lehman, Donna M., Curran, Joanne E., Duggirala, Ravindranath, Blangero, John, Carmi, Shai, Williams, Amy L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2019
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944377/
https://ncbi.nlm.nih.gov/pubmed/31860654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007979
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