Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives

Simulations of close relatives and identical by descent (IBD) segments are common in genetic studies, yet most past efforts have utilized sex averaged genetic maps and ignored crossover interference, thus omitting features known to affect the breakpoints of IBD segments. We developed Ped-sim, a meth...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Caballero, Madison, Seidman, Daniel N., Qiao, Ying, Sannerud, Jens, Dyer, Thomas D., Lehman, Donna M., Curran, Joanne E., Duggirala, Ravindranath, Blangero, John, Carmi, Shai, Williams, Amy L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944377/
https://ncbi.nlm.nih.gov/pubmed/31860654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007979
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