The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease

Synaptic dysfunction is an early pathogenic event in Alzheimer disease (AD) that contributes to network disturbances and cognitive decline. Some synapses are more vulnerable than others, including the synapses of the perforant path, which provides the main excitatory input to the hippocampus. To elu...

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Publicado en:Mol Cell Proteomics
Autores principales: Haytural, Hazal, Mermelekas, Georgios, Emre, Ceren, Nigam, Saket Milind, Carroll, Steven L., Winblad, Bengt, Bogdanovic, Nenad, Barthet, Gaël, Granholm, Ann-Charlotte, Orre, Lukas M., Tjernberg, Lars O., Frykman, Susanne
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944231/
https://ncbi.nlm.nih.gov/pubmed/31699905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001737
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