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Rational De Novo Design of a Cu-Metalloenzyme for Superoxide Dismutation

Superoxide dismutases (SODs) are highly efficient enzymes for superoxide dismutation and the first line of defense against oxidative stress. These metalloproteins contain a redox active metal ion in their active site (Mn, Cu, Fe, Ni) with a tightly controlled reduction potential found in a close ran...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Mathieu, Emilie, Tolbert, Audrey E., Koebke, Karl J., Tard, Cédric, Iranzo, Olga, Penner-Hahn, James E., Policar, Clotilde, Pecoraro, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944188/
https://ncbi.nlm.nih.gov/pubmed/31710732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201903808
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