Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

Using an established CRISPR-Cas mediated genome editing technique for streptomycetes, we explored the combinatorial biosynthesis potential of the auroramycin biosynthetic gene cluster in Streptomyces roseosporous. Auroramycin is a potent anti-MRSA polyene macrolactam. In addition, auroramycin has an...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Yeo, Wan Lin, Heng, Elena, Tan, Lee Ling, Lim, Yi Wee, Ching, Kuan Chieh, Tsai, De-Juin, Jhang, Yi Wun, Lauderdale, Tsai-Ling, Shia, Kak-Shan, Zhao, Huimin, Ang, Ee Lui, Zhang, Mingzi M., Lim, Yee Hwee, Wong, Fong T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943886/
https://ncbi.nlm.nih.gov/pubmed/31906943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-019-1274-y
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