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A Robust and Scalable High-Throughput Compatible Assay for Screening Amyloid-β-Binding Compounds

A robust fluorescent readout assay using topologically-sensitive dyes improves the screening of novel amyloid-binding molecules. One of the key components that make this assay more realistic is the use of endogenous amyloid obtained from 5XFAD mouse brains. The assay conditions were optimized for hi...

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Detaylı Bibliyografya
Yayımlandı:J Alzheimers Dis
Asıl Yazarlar: McClure, Richard, Redha, Rey, Vinson, Paige, Pham, Wellington
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943818/
https://ncbi.nlm.nih.gov/pubmed/31177230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190316
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