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A Robust and Scalable High-Throughput Compatible Assay for Screening Amyloid-β-Binding Compounds

A robust fluorescent readout assay using topologically-sensitive dyes improves the screening of novel amyloid-binding molecules. One of the key components that make this assay more realistic is the use of endogenous amyloid obtained from 5XFAD mouse brains. The assay conditions were optimized for hi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Alzheimers Dis
Egile Nagusiak: McClure, Richard, Redha, Rey, Vinson, Paige, Pham, Wellington
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943818/
https://ncbi.nlm.nih.gov/pubmed/31177230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190316
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