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A Robust and Scalable High-Throughput Compatible Assay for Screening Amyloid-β-Binding Compounds

A robust fluorescent readout assay using topologically-sensitive dyes improves the screening of novel amyloid-binding molecules. One of the key components that make this assay more realistic is the use of endogenous amyloid obtained from 5XFAD mouse brains. The assay conditions were optimized for hi...

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Vydáno v:J Alzheimers Dis
Hlavní autoři: McClure, Richard, Redha, Rey, Vinson, Paige, Pham, Wellington
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943818/
https://ncbi.nlm.nih.gov/pubmed/31177230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190316
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