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CX-5461 Inhibits Pancreatic Ductal Adenocarcinoma Cell Growth, Migration and Induces DNA Damage

Background: Inhibition of ribosome biogenesis has recently emerged as a promising strategy for the treatment of metastatic tumors. The RNA polymerase I inhibitor CX-5461 has shown efficacy in a panel of cancer types and is currently being tested in clinical trials. However, further preclinical studi...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: El Hassouni, Btissame, Mantini, Giulia, Immordino, Benoît, Peters, Godefridus J., Giovannetti, Elisa
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943431/
https://ncbi.nlm.nih.gov/pubmed/31817270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24244445
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