Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells

Pancreatic stellate cells (PSCs) are a key component of tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) and contribute to drug resistance. c-MET receptor tyrosine kinase activation plays an important role in tumorigenesis in different cancers including PDAC. In this study, effects...

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Библиографические подробности
Опубликовано в: :Cancers (Basel)
Главные авторы: Firuzi, Omidreza, Che, Pei Pei, El Hassouni, Btissame, Buijs, Mark, Coppola, Stefano, Löhr, Matthias, Funel, Niccola, Heuchel, Rainer, Carnevale, Ilaria, Schmidt, Thomas, Mantini, Giulia, Avan, Amir, Saso, Luciano, Peters, Godefridus J., Giovannetti, Elisa
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562408/
https://ncbi.nlm.nih.gov/pubmed/31072019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11050638
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