Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells

Pancreatic stellate cells (PSCs) are a key component of tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) and contribute to drug resistance. c-MET receptor tyrosine kinase activation plays an important role in tumorigenesis in different cancers including PDAC. In this study, effects...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Firuzi, Omidreza, Che, Pei Pei, El Hassouni, Btissame, Buijs, Mark, Coppola, Stefano, Löhr, Matthias, Funel, Niccola, Heuchel, Rainer, Carnevale, Ilaria, Schmidt, Thomas, Mantini, Giulia, Avan, Amir, Saso, Luciano, Peters, Godefridus J., Giovannetti, Elisa
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562408/
https://ncbi.nlm.nih.gov/pubmed/31072019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11050638
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