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Surface plasmon resonance and cytotoxicity assays of drug efficacies predicted computationally to inhibit p53/MDM2 interaction
Docking on the p53-binding site of murine double minute 2 (MDM2) by small molecules restores p53’s tumor-suppressor function. We previously assessed 3244 FDA-approved drugs via “computational conformer selection” for inhibiting MDM2 and p53 interaction. Here, we developed a surface plasmon resonance...
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| Publicado no: | Anal Biochem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6942878/ https://ncbi.nlm.nih.gov/pubmed/30721669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2019.01.012 |
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