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MDM2–MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance
Murine double minute 2 (MDM2) and 4 (MDM4) are known as the main negative regulators of p53, a tumor suppressor. They are able to form heterodimers that are much more effective in the downregulation of p53. Therefore, the MDM2–MDM4 complex could be a target for promising therapeutic restoration of p...
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| Publicat a: | Int J Nanomedicine |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Dove Medical Press
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5012629/ https://ncbi.nlm.nih.gov/pubmed/27621617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S114705 |
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