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New addiction to the NRF2‐related factor NRF3 in cancer cells: Ubiquitin‐independent proteolysis through the 20S proteasome

Accumulating evidence has revealed that human cancers develop by sequentially mutating pivotal genes, including driver genes, and acquiring cancer hallmarks. For instance, cancer cells are addicted to the transcription factor NRF2 (NFE2L2), which is a driver gene that utilizes the cellular cytoprote...

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Détails bibliographiques
Publié dans:Cancer Sci
Auteurs principaux: Kobayashi, Akira, Waku, Tsuyoshi
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942428/
https://ncbi.nlm.nih.gov/pubmed/31742837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14244
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