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New addiction to the NRF2‐related factor NRF3 in cancer cells: Ubiquitin‐independent proteolysis through the 20S proteasome

Accumulating evidence has revealed that human cancers develop by sequentially mutating pivotal genes, including driver genes, and acquiring cancer hallmarks. For instance, cancer cells are addicted to the transcription factor NRF2 (NFE2L2), which is a driver gene that utilizes the cellular cytoprote...

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Bibliografiske detaljer
Udgivet i:Cancer Sci
Main Authors: Kobayashi, Akira, Waku, Tsuyoshi
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942428/
https://ncbi.nlm.nih.gov/pubmed/31742837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14244
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