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Oxodealkenylative cleavage of alkene C(sp(3))–C(sp(2)) bonds: A practical method for introducing carbonyls into chiral pool materials

Herein we report a one-pot protocol for the oxodealkenylative introduction of carbonyl functionalities into terpenes and terpene-derived compounds. This transformation proceeds via Criegee ozonolysis of an alkene, reductive cleavage of the resulting α-alkoxy hydroperoxide, trapping of the generated...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Smaligo, Andrew J., Wu, Jason, Burton, Nikolas R., Hacker, Allison S., Shaikh, Aslam C., Quintana, Jason C., Wang, Ruoxi, Xie, Changmin, Kwon, Ohyun
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942233/
https://ncbi.nlm.nih.gov/pubmed/31692203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201913201
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