Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration

Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrheal disease among children in developing countries, and there are no licensed vaccines to protect against ETEC. Passive immunization by oral delivery of ETEC-specific secretory IgAs (sIgAs) could potentially provide an alternative app...

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Veröffentlicht in:J Pharm Sci
Hauptverfasser: Hu, Yue, Kumru, Ozan S., Xiong, Jian, Antunez, Lorena R., Hickey, John, Wang, Yang, Cavacini, Lisa, Klempner, Mark, Joshi, Sangeeta B., Volkin, David B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941217/
https://ncbi.nlm.nih.gov/pubmed/31369743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.07.018
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