Hyperglycemia-induced cardiomyocyte death is mediated by lysosomal membrane injury and aberrant expression of Cathepsin D

Hyperglycemia is an independent risk factor for diabetic heart failure. However, the mechanisms that mediate hyperglycemia-induced cardiac damage remain poorly understood. Previous studies have shown an association between lysosomal dysfunction and diabetic heart injury. The present study examined i...

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Bibliographic Details
Published in:Biochem Biophys Res Commun
Main Authors: Kobayashi, Satoru, Zhao, Fengyi, Kobayashi, Tamayo, Hagiwara, Mariko, Kaminaris, Amanda, Li, Cairong, Cai, Fei, Huang, Yuan, Liang, Qiangrong
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941191/
https://ncbi.nlm.nih.gov/pubmed/31862139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2019.12.051
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