Mitochondrial Fission and Mitophagy Coordinately Restrict High Glucose Toxicity in Cardiomyocytes

Hyperglycemia-induced mitochondrial dysfunction plays a key role in the pathogenesis of diabetic cardiomyopathy. Injured mitochondrial segments are separated by mitochondrial fission and eliminated by autophagic sequestration and subsequent degradation in the lysosome, a process termed mitophagy. Ho...

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Vydáno v:Front Physiol
Hlavní autoři: Kobayashi, Satoru, Zhao, Fengyi, Zhang, Ziying, Kobayashi, Tamayo, Huang, Yuan, Shi, Bingyin, Wu, Weihua, Liang, Qiangrong
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758327/
https://ncbi.nlm.nih.gov/pubmed/33362579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.604069
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