AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

Drug resistance is the main obstacle in the improvement of chemotherapeutic efficacy in glioblastoma. Previously, we showed that dehydroepiandrosterone (DHEA), one kind of androgen/neurosteroid, potentiates glioblastoma to acquire resistance through attenuating DNA damage. Androgen receptor (AR) act...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Chen, Tzu-Chi, Chuang, Jian-Ying, Ko, Chiung-Yuan, Kao, Tzu-Jen, Yang, Pei-Yu, Yu, Chun-Hui, Liu, Ming-Sheng, Hu, Siou-Lian, Tsai, Yu-Ting, Chan, Hardy, Chang, Wen-Chang, Hsu, Tsung-I.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940696/
https://ncbi.nlm.nih.gov/pubmed/31896509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101413
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