Curcumin analog cytotoxicity against breast cancer cells: Exploitation of a redox-dependent mechanism

A series of novel curcumin analogs, symmetrical dienones, were previously shown to possess cytotoxic, anti-angiogenic and anti-tumor activities. Analogs 1 (EF24) and 2 (EF31) share the dienone scaffold and serve as Michael acceptors. We propose that the anticancer effects of 1 and 2 are mediated in...

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Hauptverfasser: Sun, Aiming, Lu, Yang J., Hu, Haipeng, Shoji, Mamoru, Liotta, Dennis C., Snyder, James P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791955/
https://ncbi.nlm.nih.gov/pubmed/19854644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.023
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