CYP17A1 Maintains the Survival of Glioblastomas by Regulating SAR1-Mediated Endoplasmic Reticulum Health and Redox Homeostasis

Cytochrome P450 (CYP) 17A1 is an important steroidogenic enzyme harboring 17α-hydroxylase and performing 17,20 lyase activities in multiple steps of steroid hormone synthesis, including dehydroepiandrosterone (DHEA) biosynthesis. Previously, we showed that CYP17A1-mediated DHEA production clearly pr...

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Bibliografske podrobnosti
izdano v:Cancers (Basel)
Main Authors: Lin, Hong-Yi, Ko, Chiung-Yuan, Kao, Tzu-Jen, Yang, Wen-Bin, Tsai, Yu-Ting, Chuang, Jian-Ying, Hu, Siou-Lian, Yang, Pei-Yu, Lo, Wei-Lun, Hsu, Tsung-I
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6770831/
https://ncbi.nlm.nih.gov/pubmed/31527549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11091378
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