Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage

DNA damage and metabolic disorders are intimately linked with premature disease onset but the underlying mechanisms remain poorly understood. Here, we show that persistent DNA damage accumulation in tissue-infiltrating macrophages carrying an ERCC1-XPF DNA repair defect (Er1(F/−)) triggers Golgi dis...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Goulielmaki, Evi, Ioannidou, Anna, Tsekrekou, Maria, Stratigi, Kalliopi, Poutakidou, Ioanna K., Gkirtzimanaki, Katerina, Aivaliotis, Michalis, Evangelou, Konstantinos, Topalis, Pantelis, Altmüller, Janine, Gorgoulis, Vassilis G., Chatzinikolaou, Georgia, Garinis, George A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940362/
https://ncbi.nlm.nih.gov/pubmed/31896748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13894-9
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