Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage

DNA damage and metabolic disorders are intimately linked with premature disease onset but the underlying mechanisms remain poorly understood. Here, we show that persistent DNA damage accumulation in tissue-infiltrating macrophages carrying an ERCC1-XPF DNA repair defect (Er1(F/−)) triggers Golgi dis...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Goulielmaki, Evi, Ioannidou, Anna, Tsekrekou, Maria, Stratigi, Kalliopi, Poutakidou, Ioanna K., Gkirtzimanaki, Katerina, Aivaliotis, Michalis, Evangelou, Konstantinos, Topalis, Pantelis, Altmüller, Janine, Gorgoulis, Vassilis G., Chatzinikolaou, Georgia, Garinis, George A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940362/
https://ncbi.nlm.nih.gov/pubmed/31896748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13894-9
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