CD4(+) Tissue-resident Memory T Cells Expand and Are a Major Source of Mucosal Tumour Necrosis Factor α in Active Crohn’s Disease

BACKGROUND AND AIMS: Tumour necrosis factor [TNF]α- and IL-17A-producing T cells are implicated in Crohn’s disease [CD]. Tissue-resident memory T [T(RM)] cells are tissue-restricted T cells that are regulated by PR zinc finger domain 1 [PRDM1], which has been implicated in pathogenic T(h)17 cell res...

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Detalhes bibliográficos
Publicado no:J Crohns Colitis
Main Authors: Bishu, Shrinivas, El Zaatari, Mohammed, Hayashi, Atsushi, Hou, Guoqing, Bowers, Nicole, Kinnucan, Jami, Manoogian, Beth, Muza-Moons, Michelle, Zhang, Min, Grasberger, Helmut, Bourque, Charlie, Zou, Weiping, Higgins, Peter D R, Spence, Jason R, Stidham, Ryan W, Kamada, Nobuhiko, Kao, John Y
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939878/
https://ncbi.nlm.nih.gov/pubmed/30715262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjz010
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