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Fork pausing complex engages topoisomerases at the replisome
Replication forks temporarily or terminally pause at hundreds of hard-to-replicate regions around the genome. A conserved pair of budding yeast replisome components Tof1–Csm3 (fission yeast Swi1–Swi3 and human TIMELESS–TIPIN) act as a “molecular brake” and promote fork slowdown at proteinaceous repl...
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| Pubblicato in: | Genes Dev |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6938670/ https://ncbi.nlm.nih.gov/pubmed/31805522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.331868.119 |
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