Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas

Osteosarcoma (OS) patients with metastasis or recurrent tumors still suffer from poor prognosis. Studies have indicated the efficacy of DNA demethylation therapy for OS, but the underlying mechanism is still unclear. Here, we aimed to clarify the mechanism of how epigenetic therapy has therapeutic e...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Asano, Naofumi, Takeshima, Hideyuki, Yamashita, Satoshi, Takamatsu, Hironori, Hattori, Naoko, Kubo, Takashi, Yoshida, Akihiko, Kobayashi, Eisuke, Nakayama, Robert, Matsumoto, Morio, Nakamura, Masaya, Ichikawa, Hitoshi, Kawai, Akira, Kondo, Tadashi, Ushijima, Toshikazu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937291/
https://ncbi.nlm.nih.gov/pubmed/31889115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56883-0
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