Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas

Osteosarcoma (OS) patients with metastasis or recurrent tumors still suffer from poor prognosis. Studies have indicated the efficacy of DNA demethylation therapy for OS, but the underlying mechanism is still unclear. Here, we aimed to clarify the mechanism of how epigenetic therapy has therapeutic e...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Asano, Naofumi, Takeshima, Hideyuki, Yamashita, Satoshi, Takamatsu, Hironori, Hattori, Naoko, Kubo, Takashi, Yoshida, Akihiko, Kobayashi, Eisuke, Nakayama, Robert, Matsumoto, Morio, Nakamura, Masaya, Ichikawa, Hitoshi, Kawai, Akira, Kondo, Tadashi, Ushijima, Toshikazu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937291/
https://ncbi.nlm.nih.gov/pubmed/31889115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56883-0
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