Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation

RNF183 is a ubiquitin ligase containing RING-finger and transmembrane domains, and its expression levels are increased in patients with inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, and in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice. Here, we furthe...

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Published in:Sci Rep
Main Authors: Wu, Yan, Kimura, Yuka, Okamoto, Takumi, Matsuhisa, Koji, Asada, Rie, Saito, Atsushi, Sakaue, Fumika, Imaizumi, Kazunori, Kaneko, Masayuki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937276/
https://ncbi.nlm.nih.gov/pubmed/31889078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56748-6
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