IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody

Broadly neutralizing antibodies (bNAbs) protect against HIV infection in non-human primates and their efficacy may be enhanced through interaction with Fc receptors on immune cells. Antibody isotype is a modulator of this binding with the IgG3 subclass mediating potent Fc effector function and is as...

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Vydáno v:PLoS Pathog
Hlavní autoři: Richardson, Simone I., Lambson, Bronwen E., Crowley, Andrew R., Bashirova, Arman, Scheepers, Cathrine, Garrett, Nigel, Abdool Karim, Salim, Mkhize, Nonhlanhla N., Carrington, Mary, Ackerman, Margaret E., Moore, Penny L., Morris, Lynn
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936867/
https://ncbi.nlm.nih.gov/pubmed/31841557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008064
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