IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody

Broadly neutralizing antibodies (bNAbs) protect against HIV infection in non-human primates and their efficacy may be enhanced through interaction with Fc receptors on immune cells. Antibody isotype is a modulator of this binding with the IgG3 subclass mediating potent Fc effector function and is as...

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Bibliografski detalji
Izdano u:PLoS Pathog
Glavni autori: Richardson, Simone I., Lambson, Bronwen E., Crowley, Andrew R., Bashirova, Arman, Scheepers, Cathrine, Garrett, Nigel, Abdool Karim, Salim, Mkhize, Nonhlanhla N., Carrington, Mary, Ackerman, Margaret E., Moore, Penny L., Morris, Lynn
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936867/
https://ncbi.nlm.nih.gov/pubmed/31841557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008064
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