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Ability to develop broadly neutralizing HIV-1 antibodies is not restricted by the germline immunoglobulin gene repertoire()

The human immunoglobulin repertoire is vast, producing billions of unique antibodies from a limited number of germline immunoglobulin genes. The immunoglobulin heavy chain variable region (IGHV) is central to antigen binding and is comprised of 48 functional genes. Here we analyzed whether HIV-1 inf...

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Dades bibliogràfiques
Publicat a:J Immunol
Autors principals: Scheepers, Cathrine, Shrestha, Ram K., Lambson, Bronwen E., Jackson, Katherine J. L., Wright, Imogen A., Naicker, Dshanta, Goosen, Mark, Berrie, Leigh, Ismail, Arshad, Garrett, Nigel, Karim, Quarraisha Abdool, Karim, Salim S. Abdool, Moore, Penny L., Travers, Simon A., Morris, Lynn
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513073/
https://ncbi.nlm.nih.gov/pubmed/25825450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500118
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