Ability to develop broadly neutralizing HIV-1 antibodies is not restricted by the germline immunoglobulin gene repertoire()

The human immunoglobulin repertoire is vast, producing billions of unique antibodies from a limited number of germline immunoglobulin genes. The immunoglobulin heavy chain variable region (IGHV) is central to antigen binding and is comprised of 48 functional genes. Here we analyzed whether HIV-1 inf...

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Bibliografske podrobnosti
izdano v:J Immunol
Main Authors: Scheepers, Cathrine, Shrestha, Ram K., Lambson, Bronwen E., Jackson, Katherine J. L., Wright, Imogen A., Naicker, Dshanta, Goosen, Mark, Berrie, Leigh, Ismail, Arshad, Garrett, Nigel, Karim, Quarraisha Abdool, Karim, Salim S. Abdool, Moore, Penny L., Travers, Simon A., Morris, Lynn
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513073/
https://ncbi.nlm.nih.gov/pubmed/25825450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500118
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