Ability to develop broadly neutralizing HIV-1 antibodies is not restricted by the germline immunoglobulin gene repertoire()

The human immunoglobulin repertoire is vast, producing billions of unique antibodies from a limited number of germline immunoglobulin genes. The immunoglobulin heavy chain variable region (IGHV) is central to antigen binding and is comprised of 48 functional genes. Here we analyzed whether HIV-1 inf...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Scheepers, Cathrine, Shrestha, Ram K., Lambson, Bronwen E., Jackson, Katherine J. L., Wright, Imogen A., Naicker, Dshanta, Goosen, Mark, Berrie, Leigh, Ismail, Arshad, Garrett, Nigel, Karim, Quarraisha Abdool, Karim, Salim S. Abdool, Moore, Penny L., Travers, Simon A., Morris, Lynn
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513073/
https://ncbi.nlm.nih.gov/pubmed/25825450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500118
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