Evolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell development

In mammals, T cell development critically depends on the IL-7 cytokine signaling pathway. Here we describe the identification of the zebrafish ortholog of mammalian IL-7 based on chromosomal localization, deduced protein sequence, and expression patterns. To examine the biological role of il7 in tel...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Lawir, Divine-Fondzenyuy, Hess, Isabell, Sikora, Katarzyna, Iwanami, Norimasa, Siamishi, Iliana, Schorpp, Michael, Boehm, Thomas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2019
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936713/
https://ncbi.nlm.nih.gov/pubmed/31822609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915223116
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