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Transgenerational inheritance of impaired larval T cell development in zebrafish

Evidence for transgenerational inheritance of epigenetic information in vertebrates is scarce. Aberrant patterns of DNA methylation in gametes may set the stage for transmission into future generations. Here, we describe a viable hypomorphic allele of dnmt1 in zebrafish that causes widespread demeth...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Iwanami, Norimasa, Lawir, Divine-Fondzenyuy, Sikora, Katarzyna, O´Meara, Connor, Takeshita, Kohei, Schorpp, Michael, Boehm, Thomas
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7481223/
https://ncbi.nlm.nih.gov/pubmed/32908148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18289-9
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