Extensive subclonal mutational diversity in human colorectal cancer and its significance

Human colorectal cancers (CRCs) contain both clonal and subclonal mutations. Clonal driver mutations are positively selected, present in most cells, and drive malignant progression. Subclonal mutations are randomly dispersed throughout the genome, providing a vast reservoir of mutant cells that can...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Loeb, Lawrence A., Kohrn, Brendan F., Loubet-Senear, Kaitlyn J., Dunn, Yasmin J., Ahn, Eun Hyun, O’Sullivan, Jacintha N., Salk, Jesse J., Bronner, Mary P., Beckman, Robert A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936702/
https://ncbi.nlm.nih.gov/pubmed/31806761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910301116
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