Extensive subclonal mutational diversity in human colorectal cancer and its significance

Human colorectal cancers (CRCs) contain both clonal and subclonal mutations. Clonal driver mutations are positively selected, present in most cells, and drive malignant progression. Subclonal mutations are randomly dispersed throughout the genome, providing a vast reservoir of mutant cells that can...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Loeb, Lawrence A., Kohrn, Brendan F., Loubet-Senear, Kaitlyn J., Dunn, Yasmin J., Ahn, Eun Hyun, O’Sullivan, Jacintha N., Salk, Jesse J., Bronner, Mary P., Beckman, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936702/
https://ncbi.nlm.nih.gov/pubmed/31806761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910301116
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