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Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

The complement cascade is an innate immune response to remove pathogens in the peripheral immune system but also plays an important role in microglia-mediated synaptic refinement during brain development. Complement C3 is elevated in Alzheimer’s disease (AD), colocalizing with neuritic plaques, and...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Shi, Qiaoqiao, Chowdhury, Saba, Ma, Rong, Le, Kevin X., Hong, Soyon, Caldarone, Barbara J., Stevens, Beth, Lemere, Cynthia A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936623/
https://ncbi.nlm.nih.gov/pubmed/28566429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf6295
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