Neutralization of IL-1α ameliorates Crohn’s disease-like ileitis by functional alterations of the gut microbiome

Crohn’s disease and ulcerative colitis are chronic and progressive inflammatory bowel diseases (IBDs) that are attributed to dysregulated interactions between the gut microbiome and the intestinal mucosa-associated immune system. There are limited studies investigating the role of either IL-1α or IL...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Menghini, Paola, Corridoni, Daniele, Buttó, Ludovica F., Osme, Abdullah, Shivaswamy, Sushma, Lam, Minh, Bamias, Giorgos, Pizarro, Theresa T., Rodriguez-Palacios, Alexander, Dinarello, Charles A., Cominelli, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936591/
https://ncbi.nlm.nih.gov/pubmed/31843928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915043116
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