Intestinal-Specific TNFα Overexpression Induces Crohn’s-Like Ileitis in Mice

BACKGROUND AND AIM: Human and animal studies have clearly established tumor necrosis factor (TNF)α as an important mediator of Crohn’s disease pathogenesis. However, whether systemic or only local TNFα overproduction is required for the development of chronic intestinal inflammation and Crohn’s dise...

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Main Authors: Bamias, Giorgos, Dahman, Mohamed I., Arseneau, Kristen O., Guanzon, Mitchell, Gruska, Dennis, Pizarro, Theresa T., Cominelli, Fabio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748077/
https://ncbi.nlm.nih.gov/pubmed/23977323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072594
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