Intestinal-Specific TNFα Overexpression Induces Crohn’s-Like Ileitis in Mice

BACKGROUND AND AIM: Human and animal studies have clearly established tumor necrosis factor (TNF)α as an important mediator of Crohn’s disease pathogenesis. However, whether systemic or only local TNFα overproduction is required for the development of chronic intestinal inflammation and Crohn’s dise...

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Bibliographic Details
Main Authors: Bamias, Giorgos, Dahman, Mohamed I., Arseneau, Kristen O., Guanzon, Mitchell, Gruska, Dennis, Pizarro, Theresa T., Cominelli, Fabio
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748077/
https://ncbi.nlm.nih.gov/pubmed/23977323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072594
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