Death-Domain-Receptor 3 Deletion Normalizes Inflammatory Gene Expression and Prevents Ileitis in Experimental Crohn’s Disease

BACKGROUND: TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain-receptor-3 (DR3), are multifunctional mediators of effector and regulatory immunity. We aimed to evaluate the functional role and therapeutic potential of TL1A/DR3 signaling in Crohn’s disease–like ileitis. METHODS: Il...

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Detalles Bibliográficos
Publicado en:Inflamm Bowel Dis
Main Authors: Buttó, Ludovica F, Jia, Li-Guo, Arseneau, Kristen O, Tamagawa, Hiroshi, Rodriguez-Palacios, Alex, Li, Zhaodong, De Salvo, Carlo, Pizarro, Theresa T, Bamias, Giorgos, Cominelli, Fabio
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Leading off
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290789/
https://ncbi.nlm.nih.gov/pubmed/30295722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ibd/izy305
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