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Death-Domain-Receptor 3 Deletion Normalizes Inflammatory Gene Expression and Prevents Ileitis in Experimental Crohn’s Disease

BACKGROUND: TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain-receptor-3 (DR3), are multifunctional mediators of effector and regulatory immunity. We aimed to evaluate the functional role and therapeutic potential of TL1A/DR3 signaling in Crohn’s disease–like ileitis. METHODS: Il...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Inflamm Bowel Dis
Main Authors: Buttó, Ludovica F, Jia, Li-Guo, Arseneau, Kristen O, Tamagawa, Hiroshi, Rodriguez-Palacios, Alex, Li, Zhaodong, De Salvo, Carlo, Pizarro, Theresa T, Bamias, Giorgos, Cominelli, Fabio
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290789/
https://ncbi.nlm.nih.gov/pubmed/30295722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ibd/izy305
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