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COMBINED HYDROXYUREA AND ET(A) RECEPTOR BLOCKADE REDUCES RENAL INJURY IN THE HUMANIZED SICKLE CELL MOUSE
AIM: The objective of this study is to determine if ambrisentan (ET(A) selective antagonist) and hydroxyurea (HU) treatment has a synergistic effect on renal injury in SCN when compared to HU treatment alone. The premise of the study is based on recent findings show that endothelin-1 (ET-1) contribu...
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| Publicado no: | Acta Physiol (Oxf) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6936325/ https://ncbi.nlm.nih.gov/pubmed/30144292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apha.13178 |
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